姓名：韩国成

个人简介

韩国成，男，1981年生，博士，教授，博士生导师。2004年毕业于武汉工程大学，同年进入桂林理工大学攻读硕士学位，2007年毕业进入中南大学化学化工学院攻读博士学位，2009年9月到2010年9月作为国家公派联合培养博士生在加拿大西安大略大学化学系Heinz-BernhardKraatz研究小组里学习一年，主要从事生物分子检测工作。2011年6月获得应用化学博士学位，同年7月进入桂林电子科技大学生命与环境科学学院从事教学和科研工作。2012年12月晋升副教授，2017年12月晋升教授，2018年入选广西高等学校千名中青年骨干教师培育计划人选。

      近几年来，主要从事生物医学工程、电化学生物传感器和电分析化学的研究工作。主持国家自然科学基金-地区科学基金项目一项“用于C-反应蛋白检测的电化学生物传感器研究(61661014，已结题)”，主持国家自然科学基金-青年科学基金项目一项“用于糖化血红蛋白检测的新型电化学生物传感器研究(61301038，已结题)”，主持广西区自然科学基金-面上项目一项“抗坏血酸、多巴胺、尿酸和色氨酸电化学同步检测研究(2018GXNSFAA281198)”和青年科学基金项目一项“巯基化合物的快速定量检测研究(2015GXNSFBA139041，已结题)”。在电化学生物传感器、电分析化学性质研究及生物体内功能分子的检测方面取得了一些的成绩，部分研究成果已经发表在国内外的知名刊物上，如Sensorsand Actuators B: Chemical, Journal of Cleaner Production, Journal ofBiomedical Nanotechnology, Analytica Chimica Acta, InternationalJournal of Nanomedicine, Sensors, European Journal of InorganicChemistry, Journal of The Electrochemical Society, InternationalJournal of Electrochemical Science, Applied Surface Science, Journalof Cluster Science, Thin Solid Films,Luminescence等。共发表SCI论文60篇，其中通讯作者或第一作者论文50篇，全部论文SCI他引600余次。

        近年来相关研究工作及取得的成果如下：

(1)  基于信号放大技术的生物分子电化学检测  

       成功运用纳米材料的信号放大技术实现了血红蛋白、β-淀粉样蛋白、C反应蛋白、凝血酶的电化学方法检测。对活化后的丝网印刷电极通过恒电位沉积的方法将纳米金修饰在电极表面，并将电活性物质滴加在电极表面，最后将血红蛋白固定在传感器上，利用差分脉冲伏安法实现对血红蛋白的检测。研究成果发表在国际top期刊 “Sensorsand Actuators B: Chemical, 2019, 282: 130-136”上(2019IF=6.393)，题目为“Disposableelectrochemical sensors for hemoglobin detection based on ferrocenoylcysteine conjugates modifiedelectrode”。所取得的结果进一步完善电化学传感器的理论和技术，丰富了血红蛋白的检测方法。基于抑制肽引发的银纳米颗粒原位组装方法，开发了一种高灵敏和选择性电化学生物传感器用于β-淀粉样寡聚物的检测。具体来说，固定在电极表面并呈现在溶液中的肽一起触发AgNP聚集体的原位形成，产生明显的电化学信号，然而，Aβ寡聚物与固定化肽的特异性结合阻止了AgNPs的原位组装导致电化学信号的明显减弱，从而实现Aβ寡聚物的检测，研究结果发表在“InternationalJournal of Nanomedicine, 2017, 12: 3171-3179”上，论文题目为：Asensitive and selective electrochemical biosensor for thedetermination of beta-amyloid oligomer by inhibiting thepeptide-triggered in situ assembly of silvernanoparticles。通过自组装的方法依次将L-半胱氨酸、戊二醛、Anti-CRP固定在裸金电极的表面，制备成电化学免疫传感器，利用交流阻抗技术检测Ab-CRP，研究成果发表在Journalof The Electrochemical Society, 2014, 161 (5): B75-B80上，题目为：TowardsLabel-Free Impedance Biosensors: CRP Probe Based on ThiolSchiff-Nickel Complex Modified Gold Nanoparticles。将小分子多肽SGFPRGRYC偶联在二茂铁上，形成Fc-SGFPRGRYC，并通过Au-S键固定在裸金电极上，在凝血酶的作用下，对小分子多肽进行切割，形成Fc-SGFPR和GRYC片段，在这个过程中会伴随着电化学信号的改变，通过电化学-化学-化学氧化还原循环法实现电化学信号的放大，从而提高蛋白酶检测的灵敏度，该研究结果发表在InternationalJournal of Electrochemical Science, 2016, 11:8646-8653上，题目为：ElectrochemicalDetermination of Protease with Improving Sensitivity byElectrochemical-chemical-chemical Redox Cycling。

       成功运用小分子电活性物质的信号放大技术实现了抗坏血酸、多巴胺、尿酸、葡萄糖、NO₂^-的电化学方法检测。电化学沉积的方法将电活性物质血红素(heme)直接修饰于玻碳电极（GCE）上，由于heme的信号放大性能，实现三者（抗坏血酸、多巴胺、尿酸）氧化峰信号放大和氧化峰分离，基于此建立一种同时检测抗坏血酸、多巴胺、尿酸的电化学方法。研究结果发表在Journalof Biomedical Nanotechnology, 2020, 16(1), 29-39上，题目为：Real-timeElectrochemical Detection of Uric Acid, Dopamine and Ascorbic Acid byHeme Directly Modified CarbonElectrode。制备了一种新的3D纸基微流控葡萄糖传感器，rGO-TEPA/PB修饰SPEs，在其纸醛基化亲水区固定葡萄糖氧化酶，实现葡萄糖溶液检测，0.1mM-25mM，检测限为25μM。研究结果发表在AnalyticaChimica Acta, 2020, 1096:34-43(IF=5.256)上，题目为：Anovel 3D paper-based microfluidic electrochemical glucose biosensorbased on rGO-TEPA/PB sensitive film。采用二茂铁衍生物(Fc-ECG)修饰丝网印刷电极，采用电化学方法实现对榨菜汁液中NO₂^-的检测，研究结果发表在"Sensors,2019, 19, 268"上，论文题目为"AFacile Electrochemical Sensor Labeled by Ferrocenoyl CysteineConjugate for the Detection of Nitrite in Pickle Juice"。并对G-四链体-血红素DNA酶检测的电化学传感器近期相关研究工作进行了综述，发表在InternationalJournal of Electrochemical Science, 2015, 10:3897-3913上，题目为Hemin/G-quadruplex DNAzyme for Designing of ElectrochemicalSensors。以上这些工作为本项目中电化学法检测葡萄糖奠定了比较扎实的基础。

(2)  光谱和色谱法检测小分子化合物  

       荧光光谱法检测低分子量巯基化合物，即将稀土铈作为荧光探针，根据Ce(III)-RSSR化合物荧光强度随着巯基化合物的浓度变化而变化，通过荧光光谱法确定低分子量巯基化合物的浓度，该方法简单、快捷、灵敏，该研究工作发表在AnalyticaChimica Acta, 2010,659: 238-242和Luminescence,2009, 25:389-393上，题目分别为Spectrofluorimetricdetermination of total free thiols based on formation of complexes ofCe(III) with disulfide bonds和Synthesis,characterization and fluorescent properties of cerium(III)glutathionecomplex。通过紫外-可见光谱法研究了二茂铁衍生物和血红素、BSA相互作用情况，研究成果发表在Spectroscopyand Spectral Analysis, 2016, 36(5): 1585~1591和2018,38(12):3958-3962上，题目分别为：InteractionStudy of Ferrocene Derivatives and Heme by UV-VisSpectroscopy和InteractionStudy of Fc(COOH)₂ andBSA by UV-vis Spectroscopy。

(3)  有机及无机合成

       结合广西区域生物材料特色物质剑麻纤维，创造性地研制出具有良好导电性能的铅碳电池负极材料，为生物传感器制备中所需的基底材料奠定了良好的基础。研究成果发表在国际top期刊 Journalof Cleaner Production, 2018, 197(1):332-338上(2018IF=6.395)，题目为“Afacile method for preparation of doped-N carbon material based onsisal and application for lead-carbonbattery”。在二茂铁衍生物的合成、电化学性质和空间构型研究及与金属离子的相互作用方面做的研究工作，结果发表在EuropeanJournal of Inorganic Chemistry, 2014, 31:5337-5347上，题目为Synthesis,Characterization of Some Ferrocenoyl Cysteine and HistidineConjugates, and Their Interactions with Some MetalIons。采用化学共沉淀法合成磁性纳米粒子，同时用羧甲基化的葡聚糖对纳米粒子进行改性，通过酰胺缩合反应固定生长抑制素类药物奥曲肽。在药物奥曲肽与胰腺癌细胞特异的相互作用下，将磁性纳米粒子带入细胞内，采用透射电镜和磁共振成像技术检测药物的固定效果以及药物和癌细胞的特异性作用，研究结果发表在EuropeanJournal of Inorganic Chemistry, 2010, 24:5455-5461上，题目为Carboxymethyl-DextranModified Magnetic Nanoparticle Conjugated to Octreotide for MRIApplications。

教育背景

2010/09-2011/06，中南大学，化学化工学院，博士

2009/09-2010/09，加拿大西安大略大学(WesternUniversity), 化学系，博士

2007/09-2009/08，中南大学，化学化工学院，博士

2004/09-2007/06，桂林理工大学，化学与生物工程学院，硕士

2000/09-2004/06，武汉工程大学，制药与化工学院，学士

工作经历

2017/12-至今,桂林电子科技大学,生命与环境科学学院,教授

2012.12-2017.11,桂林电子科技大学,生命与环境科学学院,副教授

2011/07-2012/10，桂林电子科技大学,生命与环境科学学院,讲师

主要荣誉

指导本科生参加2018-2013年广西高校化学化工类论文及设计竞赛，获一等奖1项，二等奖3项，三等奖1项。2015年和2017年，获桂林电子科技大学本科课堂教学质量优秀奖二等奖2项，2017年获校级教学成果奖三等奖2项。 2018获得桂林电子科技大学优秀党员荣誉称号。2021获广西自然科学奖二等奖1项。2022获中国自动化学会自然科学奖二等奖1项。

学术活动

中国化学会、中国自动化学会、中国生物医学工程学会健康工程分会委员，担任MPDI数据库审稿专家，Sustainability客座编辑。

教学信息

本科教学，主讲《基因组学》，《生物信息学（外文教材）》，《药学专业英语》，《药理学（外文教材）》，《生物化学》，《普通化学》。

研究生教学，《专业英语》，《高等分子生物学》，《生物医学工程前沿》。

主要论文

2022

[63]Z. F. Zhou, X. Z. Feng, T. Zhan, G. C. Han, Z. C. Chen, H. B. Kraatz,Facile bimetallic co-amplified electrochemical sensor for folic acidsensing based on CoNPs and CuNPs, Analytical and BioanalyticalChemistry, 414(2022) 6791-6800.

[62]T. Zhan, X. Z. Feng, Y. Y. Cheng, G. C. Han, Z. C. Chen, H. B.Kraatz, Synergistic Electrochemical Amplification of FerroceneCarboxylic Acid Nanoflowers and Cu Nanoparticles for Folic AcidSensing, Journal of the Electrochemical Society, 169(2022).

[61]T. Zhan, X. Z. Feng, Q. Q. An, S. Y. Li, M. Y. Xue, Z. C. Chen, etal., Enzyme-free glucose sensors with efficient synergisticelectro-catalysis based on a ferrocene derivative and two metalnanoparticles, Rsc Advances, 12(2022) 5072-5079.

[60]R. Z. Wei, Z. Liu, W. C. Wei, S. Wang, Y. J. Lv, G. C. Han,Anticorrosion performance of hydrophobic acid-modified-MOFs/epoxycoatings, Colloid and Interface Science Communications, 46(2022).

[59]S. Wang, R. Q. Huang, W. Li, Y. J. Lv, G. C. Han, R. Z. Wei, et al.,Synthesis, structure and properties of two complexes based on N and Sheterocyclic dicarboxylic acid ligands, Molecular Crystals and LiquidCrystals, (2022).

[58]D. Sun, R. T. Guo, Y. J. Lv, W. Li, M. J. Lu, Q. M. Wei, et al.,Na2MnPO4F/Ti3C2-CQDs composite cathode material with enhancedelectrochemical properties for lithium/sodium hybrid ion battery,Diamond and Related Materials, 128(2022).

[57]Q. M. Lin, X. Z. Feng, F. L. Chen, K. H. Song, G. C. Han, Z. C. Chen,et al., A Novel Electrochemical Strategy for ChloramphenicolDetection in a Water Environment Based on Silver Nanoparticles andThiophene, Journal of the Electrochemical Society, 169(2022).

[56]R. T. Guo, W. Li, M. J. Lu, Y. J. Lv, H. T. Ai, D. Sun, et al.,Na3V2(PO4)(2)F-3@bagasse carbon as cathode material forlithium/sodium hybrid ion battery, Physical Chemistry ChemicalPhysics, 24(2022) 5638-5645.

[55]Q. Q. An, X. Z. Feng, Z. F. Zhou, T. Zhan, S. F. Lian, J. M. Zhu, etal., One step construction of an electrochemical sensor for melaminedetection in milk towards an integrated portable system, FoodChemistry, 383(2022).

[54]D. Sun, W. Li, R. T. Guo, Q. Q. Liang, Z. Liu, G. C. Han, Preparationof N-doped biomass C@SnO2 composites and its electrochemicalperformance, Diamond and Related Materials, 120(2021).

[53]J. G. Liu, J. Z. Wan, Q. M. Lin, G. C. Han, X. Z. Feng, Z. C. Chen,Convenient Heme Nanorod Modified Electrode for Quercetin Sensing byTwo Common Electrochemical Methods, Micromachines, 12(2021).

2021

[52]Y. Y. Cheng, T. Zhan, X. Z. Feng, G. C. Han, A synergistic effect ofgold nanoparticles and melamine with signal amplifification forC-reactive protein sensing, Journal of Electroanalytical Chemistry,895(2021) 115417.

[51]R. Z. Wei, Z. Liu, W. C. Wei, C. X. Liang, G. C. Han, L. Zhan,Synthesis, Crystal Structure and Characterization of Two Cobalt (II)Complexes Based on Pyridine Carboxylic Acid Ligands, Zeitschrift FurAnorganische Und Allgemeine Chemie, (2021).DOI:10.1002/zaac.202000418

[50]W. C. Wei, Z. Liu, R. Z. Wei, C. X. Liang, X. Z. Feng, G. C. Han,Synthesis, crystal structure and anticorrosion performance of Zn(II)and Ni(II) complexes, Journal Of Molecular Structure, 1228(2021)129452.

[49]Z. S. Chen, K. H. He, R. Z. Wei, Y. J. Lv, Z. Liu, G. C. Han,Synthesis of Mn-MOFs loaded zinc phosphate composite for water-basedacrylic coatings with durable anticorrosion performance on mildsteel, Rsc Advances, 11(2021) 3371-3379.

[48]H. T. Ai, W. Li, Z. Liu, D. Sun, H. Z. Zhou, G. C. Han, A newlithium-ion batteries derivated from waste bagasse: Preparation,characterization and application, Journal Of Alloys And Compounds,854(2021) 157156.

2020

[47]W. C. Wei, Z. Liu, R. Z. Wei, G. C. Han, C. X. Liang, Synthesis ofMOFs/GO composite for corrosion resistance application on carbonsteel, Rsc Advances, 10(2020) 29923-29934.

[46]W. C. Wei, Z. Liu, C. X. Liang, G. C. Han, Y. K. Li, Q. W. Li, etal., Corrosion Inhibition Performance of Nitrogen-Containing MetalOrganic Framework Compounds on Copper Flakes in Dilute HCl Medium,Protection Of Metals And Physical Chemistry Of Surfaces, 56(2020)638-650.

[45]W. C. Wei, Z. Liu, C. X. Liang, G. C. Han, J. X. Han, S. F. Zhang,Synthesis, characterization and corrosion inhibition behavior of2-aminofluorene bis-Schiff bases in circulating cooling water, RscAdvances, 10(2020) 17816-17828.

[44]G. C. Han, H. F. Li, A. Ferranco, T. Zhan, Y. Y. Cheng, Z. C. Chen,et al., The construction of a simple sensor for the simultaneousdetection of nitrite and thiosulfate by heme catalysis, Rsc Advances,10(2020) 35007-35016.

[43]X. Z. Feng, X. R. Su, A. Ferranco, Z. C. Chen, G. C. Han, Z. L.Jiang, et al., Real-Time Electrochemical Detection of Uric Acid,Dopamine and Ascorbic Acid by Heme Directly Modified CarbonElectrode, Journal Of Biomedical Nanotechnology, 16(2020) 29-39.

[42]X. Z. Feng, H. F. Li, A. Ferranco, Z. C. Chen, M. Y. Xue, G. C. Han,et al., A Very Simple Method for Detection of Bisphenol A inEnvironmental Water by Heme Signal Amplification, Journal Of theElectrochemical Society, 167(2020) 067503.

[41]L. L. Cao, G. C. Han, H. L. Xiao, Z. C. Chen, C. Fang, A novel 3Dpaper-based microfluidic electrochemical glucose biosensor based onrGO-TEPA/PB sensitive film, Analytica Chimica Acta, 1096(2020) 34-43.

2019

[40]Q. Q. Liang, Z. Liu, C. X. Liang, G. C. Han, S. F. Zhang, X. Z. Feng,Electrochemical Simultaneous Detection of Paracetamol and4-aminophenol Based on bis-Schiff Base Cobalt Complex, InternationalJournal Of Electrochemical Science, 14(2019) 7178-7201.

[39]C. X. Liang, Z. Liu, Q. Q. Liang, G. C. Han, J. X. Han, S. F. Zhang,et al., Synthesis of 2-aminofluorene bis-Schiff base and corrosioninhibition performance for carbon steel in HCl, Journal Of MolecularLiquids, 277(2019) 330-340.

[38]G. C. Han, X. R. Su, J. T. Hou, A. Ferranco, X. Z. Feng, R. S. Zeng,et al., Disposable electrochemical sensors for hemoglobin detectionbased on ferrocenoyl cysteine conjugates modified electrode, SensorsAnd Actuators B-Chemical, 282(2019) 130-136.

[37]X. Z. Feng, A. Ferranco, X. R. Su, Z. C. Chen, Z. L. Jiang, G. C.Han, A Facile Electrochemical Sensor Labeled by Ferrocenoyl CysteineConjugate for the Detection of Nitrite in Pickle Juice, Sensors,19(2019) 268.

[36]Z. C. Chen, Y. Bai, F. J. Zhao, L. L. Cao, G. C. Han, S. M. Yin,Disposable Amperometric Immunosensor for Hepatitis B AntigenDetection Based on Multiwalled Carbon Nanotubes and FerroceneDecorated Screen Printed Electrode, Journal Of BiomedicalNanotechnology, 15(2019) 930-938.

2018

[35]L. Zheng, J. X. Han, H. Y. Li, G. C. Han, Z. N. Guo, S. F. Zhang, etal., Synthesis, crystal structure and properties of rare earthmetal-organic framework materials based on the2,5-pyridinedicarboxylic acid ligands, Molecular Crystals And LiquidCrystals, 666(2018) 109-118.

[34]F. J. Zhao, Y. Bai, R. S. Zeng, L. L. Cao, J. M. Zhu, G. C. Han, etal., An Electrochemical Immunosensor withGraphene-Oxide-Ferrocene-based Nanocomposites for Hepatitis B SurfaceAntigen Detection, Electroanalysis, 30(2018) 2774-2780.

[33]H. Wang, Z. Liu, Q. Q. Liang, H. Y. Zhong, G. C. Han, S. F. Zhang, etal., A facile method for preparation of doped-N carbon material basedon sisal and application for lead-carbon battery, Journal Of CleanerProduction, 197(2018) 332-338.

[32]H. Wang, Z. Liu, Q. Q. Liang, G. C. Han, P. Guo, X. Q. Lao, et al.,Electrocatalytic Oxidation of L-cysteine by Adamantane Ester SchiffBase Nickel Complexes, International Journal Of ElectrochemicalScience, 13(2018) 10454-10469.

[31]H. Wang, Z. Liu, H. Y. Li, G. C. Han, L. Yun, H. Y. Zhong,Electrochemical Performance of Lead-Carbon Battery with ChitosanComposite Carbon/Lead Negative Plate, International Journal OfElectrochemical Science, 13(2018) 136-146.

[30]G. C. Han, X. R. Su, J. T. Hou, X. Z. Feng, Z. C. Chen, InteractionStudy of Fc(COOH)(2) and BSA by UV-Vis Spectroscopy, Spectroscopy AndSpectral Analysis, 38(2018) 3958-3962.

2017

[29]Y. Xing, X. Z. Feng, L. P. Zhang, J. T. Hou, G. C. Han, Z. C. Chen, Asensitive and selective electrochemical biosensor for thedetermination of beta-amyloid oligomer by inhibiting thepeptide-triggered in situ assembly of silver nanoparticles,International Journal Of Nanomedicine, 12(2017) 3171-3179.

[28]H. Y. Li, Z. Liu, H. Wang, G. C. Han, Y. Zhao, S. W. Xie, et al.,Molecular Dynamics Simulation of Adsorption Behavior of Schiff baseGemini Surfactants on Zn (110) Surface, International Journal OfElectrochemical Science, 12(2017) 6622-6637.

[27]J. X. Han, Z. Liu, Y. J. Guo, G. C. Han, W. Li, S. Y. Chen, et al.,Determination of superoxide anion radical by modified CdTe quantumdots, Journal Of Photochemistry And Photobiology a-Chemistry,349(2017) 1-6.

[26]G. C. Han, J. T. Hou, Z. L. Huang, X. Z. Feng, Z. C. Chen, W. X.Xiao, et al., Electrochemical Behaviors of Ferrocene Dicarboxylateand its Application for Heme Detection, International Journal OfElectrochemical Science, 12(2017) 6245-6254.

2016

[25]J. Zhang, Z. Liu, G. C. Han, S. L. Chen, Z. C. Chen, Inhibition ofcopper corrosion by the formation of Schiff base self-assembledmonolayers, Applied Surface Science, 389(2016) 601-608.

[24]R. S. Zeng, Z. G. Sun, C. J. Zhou, C. Fang, G. C. Han, Z. C. Chen,Well-resolved oil-soluble Au-doped ZnCdS quantum dots and enhancingdoping emission with In-codoping, Journal Of Alloys And Compounds,671(2016) 66-73.

[23]Z. Liu, Y. Zhao, G. C. Han, J. Liu, Q. Y. He, C. Z. Chen, Preparationof Schiff base surfactant and its application in alkaline zinc-nickelbatteries, Ionics, 22(2016) 2391-2397.

[22]M. La, Y. Q. Hao, Z. Y. Wang, G. C. Han, L. B. Qu, Selective andSensitive Detection of Cyanide Based on the Displacement StrategyUsing a Water-Soluble Fluorescent Probe, Journal Of AnalyticalMethods In Chemistry, 2016(2016) 1462013.

[21]G. C. Han, J. T. Hou, X. Z. Feng, Z. L. Huang, W. Gu, Z. C. Chen,Electrochemical Determination of Protease with Improving Sensitivityby Electrochemical-chemical-chemical Redox Cycling, InternationalJournal Of Electrochemical Science, 11(2016) 8646-8653.

[20]G. C. Han, X. Z. Feng, J. T. Liang, W. X. Xiao, Z. C. Chen,Interaction Study of Ferrocene Derivatives and Heme by UV-VisSpectroscopy, Spectroscopy And Spectral Analysis, 36(2016) 1585-1591.

[19]Y. J. Guo, Z. Liu, G. C. Han, W. Li, Y. J. Hu, Z. C. Chen, A NewFluorescent Switch for Determination of Pb2+ Based on Modified CdTeQuantum Dots, Journal Of Nanoscience And Nanotechnology, 16(2016)12172-12178.

[18]X. Z. Feng, G. C. Han, J. H. Qin, S. M. Yin, Z. C. Chen,Determination of Residual Solvents in Linezolid by Static HeadspaceGC, Journal Of Chromatographic Science, 54(2016) 487-491.

2015

[17]X. Y. Zhao, W. Liu, B. B. Zhou, S. S. Liu, G. C. Han, ElectrochemicalMicroRNAs Biosensors Based on Enzymatic Signal Amplification,International Journal Of Electrochemical Science, 10(2015) 8910-8925.

[16]S. W. Xie, Z. Liu, G. C. Han, W. Li, J. Liu, Z. C. Chen, Moleculardynamics simulation of inhibition mechanism of 3,5-dibromosalicylaldehyde Schiff's base, Computational And TheoreticalChemistry, 1063(2015) 50-62.

[15]L. Y. Lai, Z. Liu, G. C. Han, Z. C. Chen, Synthesis, CrystalStructure and Properties of Three Metal Complexes Based on a FlexibleSchiff Base Ligand, Journal Of Cluster Science, 26(2015) 1845-1855.

[14]L. Y. Lai, Z. Liu, G. C. Han, Crystal structure of {4,4 ',6,6'-tetrabromido-2,2-[ethane-1,4-diyl(nitrilomethanylylidene)-1-ethylamine-2-methoxyl]diphenolato-kappaO-5,N,N ',N '',O '} zinc(II) - dimethylformamide (2:1),C41H45Br8N7O7Zn2, Zeitschrift Fur Kristallographie-New CrystalStructures, 230(2015) 189-191.

[13]G. C. Han, X. Z. Feng, Z. C. Chen, Hemin/G-quadruplex DNAzyme forDesigning of Electrochemical Sensors, International Journal OfElectrochemical Science, 10(2015) 3897-3913.

2014前

[12]Z. Liu, W. Li, G. C. Han, S. Yuan, Z. C. Chen, Towards Label-FreeImpedance Biosensors: CRP Probe Based on Thiol Schiff-Nickel ComplexModified Gold Nanoparticles, Journal Of the Electrochemical Society,161(2014) B75-B80.

[11]G. C. Han, A. Ferranco, X. Z. Feng, Z. C. Chen, H. B. Kraatz,Synthesis, Characterization of Some Ferrocenoyl Cysteine andHistidine Conjugates, and Their Interactions with Some Metal Ions,European Journal Of Inorganic Chemistry, 31(2014) 5337-5347.

[10]S. L. Chen, Z. Liu, G. C. Han, Synthesis, characterization, crystalstructure and theoretical approach of(E)-2-[(3-carboxylphenylimino)methylene]phenoxyacetic acid, JournalOf Molecular Structure, 1032(2013) 246-253.

[9]S. L. Chen, Z. Liu, J. Liu, G. C. Han, Y. H. Li, Synthesis,characterization, crystal structure and theoretical approach ofCu(II) complex with4-{(Z)-[(2-hydroxybenzoyl)hydrazono]methyl}benzoic acid, Journal OfMolecular Structure, 1014(2012) 110-118.

[8]S. L. Chen, Z. Liu, G. C. Han, Synthesis, Crystal Structure andProperties of a Novel Tetranuclear Nickel(II) Complex withAzo-enolic-2-hydroxybenzamide, Chinese Journal Of StructuralChemistry, 31(2012) 1641-1649.

[7]X. Y. Zhou, Z. Liu, M. M. Wang, Y. H. Li, G. C. Han, X. Z. Feng,Polymorphism of flucloxacillin sodium, Pharmazie, 66(2011) 933-935.

[6]H. D. Lu, Y. P. Liu, G. C. Han, Optical and electrochemicalproperties of ordered macroporous gold array on the ITO surface,Applied Surface Science, 257(2011) 7030-7035.

[5]B. Y. Liu, Z. Liu, G. C. Han, Y. H. Li, Corrosion inhibition andadsorption behavior of 2-((dehydroabietylamine)methyl)-6-methoxyphenol on mild steel surface in seawater, Thin SolidFilms, 519(2011) 7836-7844.

[4]B. Y. Liu, Z. Liu, G. C. Han, Y. H. Li, Synthesis, spectroscopicproperties, crystal structure and density functional studies ofCu(II) complex with 2-((dehydroabietylamine)methyl)-6-methoxyphenol,Journal Of Molecular Structure, 975(2010) 194-199.

[3]G. C. Han, Y. Peng, Y. Q. Hao, Y. N. Liu, F. M. Zhou,Spectrofluorimetric determination of total free thiols based onformation of complexes of Ce(III) with disulfide bonds, AnalyticaChimica Acta, 659(2010) 238-242.

[2]G. C. Han, Y. Ouyang, X. Y. Long, Y. Zhou, M. Li, Y. N. Liu, et al.,(Carboxymethyl-Dextran)-Modified Magnetic Nanoparticles Conjugated toOctreotide for MRI Applications, European Journal Of InorganicChemistry, (2010) 5455-5461.

[1]G. C. Han, Y. N. Liu, Synthesis, characterization and fluorescentproperties of cerium(III) glutathione complex, Luminescence, 25(2010)389-393.

科研项目

1、国家自然科学基金-地区科学基金项目，61661014、用于C-反应蛋白检测的电化学生物传感器研究，2017/01-2020/12、38万、已结题、主持。

2、国家自然科学基金-青年科学基金项目，61301038、用于糖化血红蛋白检测的新型电化学生物传感器研究、2014/01-2016/12、26万元、已结题、主持。

3、广西自然科学基金-面上项目，2018GXNSFAA281198、抗坏血酸、多巴胺、尿酸和色氨酸电化学同步检测研究，2019/01-2021/12、12万、在研、主持。

4、广西自然科学基金-青年科学基金项目，2015GXNSFBA139041、巯基化合物的快速定量检测研究、2015/09-2018/08、5万元、已结题、主持。 

5、国家自然科学基金-地区科学基金项目，21265003，血清低密度脂蛋白胆固醇检测的电化学生物传感器研究，2013/01-2016/12，50万元，已结题，参加。

6、国家自然科学基金-地区科学基金项目，61265006，基于FPGA的傅里叶变换成像光谱仪实时数据处理系统研究，2013/01-2016/12，48万元，已结题，参加。

7、国家自然科学基金-青年科学基金，31200412，丰富度模型在南亚热带常绿阔叶林和热带雨林的预测效率评估，2013/01-2015/12，27万元，已结题，参加

知识产权

1.发明专利：韩国成，冯小珍，侯嘉婷，陈真诚，周治德。一种基于电化学探针检测还原型谷胱甘肽的方法，专利号：ZL201610764935.6。

2.发明专利：韩国成，詹涛，何彦龙，冯小珍，陈真诚，周治德。一种基于Fc-ECG/MEL/AuNPs/SPE修饰电极检测C-反应蛋白的方法，专利号：ZL202010932791.7

联系信息

电话：18707733738

邮箱：hangc81@guet.edu.cn ；hangc1981@163.com

QQ：157542957

常用链接

https://orcid.org/0000-0002-5943-8547